Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC4905459 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Li Jinqing J Liao Yuan Y Ding Tong T Wang Bo B Yu Xingjuan X Chu Yifan Y Xu Jing J Zheng Limin L
Oncotarget 20160301 10
Interleukin-25 (IL-25) is a recently identified member of the proinflammatory IL-17 cytokine family; however, its role in human tumors remains largely unknown. The aim of this study was to investigate the cellular source and clinical significance of IL-25 in gastric cancer (GC) in situ. The results demonstrated that macrophages (Mφs) were the primary IL-25-expressing cells (IL-25+) in GC in situ. Moreover, IL-25+ cells were highly enriched in the intra-tumoral (IT) region of GC tissues (p < 0.00 ...[more]