Ontology highlight
ABSTRACT:
SUBMITTER: Tang W
PROVIDER: S-EPMC4906242 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Tang Willcyn W Thevathasan Jervis Vermal JV Lin Qingshu Q Lim Kim Buay KB Kuroda Keisuke K Kaibuchi Kozo K Bilger Marcel M Soong Tuck Wah TW Fivaz Marc M
Frontiers in synaptic neuroscience 20160614
Lesions and mutations of the DISC1 (Disrupted-in-schizophrenia-1) gene have been linked to major depression, schizophrenia, bipolar disorder and autism, but the influence of DISC1 on synaptic transmission remains poorly understood. Using two independent genetic approaches-RNAi and a DISC1 KO mouse-we examined the impact of DISC1 on the synaptic vesicle (SV) cycle by population imaging of the synaptic tracer vGpH in hippocampal neurons. DISC1 loss-of-function resulted in a marked decrease in SV e ...[more]