A Comparative Structure/Function Analysis of Two Type IV Pilin DNA Receptors Defines a Novel Mode of DNA Binding.
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ABSTRACT:
SUBMITTER: Berry JL
PROVIDER: S-EPMC4906244 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
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A Comparative Structure/Function Analysis of Two Type IV Pilin DNA Receptors Defines a Novel Mode of DNA Binding.
Berry Jamie-Lee JL Xu Yingqi Y Ward Philip N PN Lea Susan M SM Matthews Stephen J SJ Pelicic Vladimir V
Structure (London, England : 1993) 20160505 6
DNA transformation is a widespread process allowing bacteria to capture free DNA by using filamentous nano-machines composed of type IV pilins. These proteins can act as DNA receptors as demonstrated by the finding that Neisseria meningitidis ComP minor pilin has intrinsic DNA-binding ability. ComP binds DNA better when it contains the DNA-uptake sequence (DUS) motif abundant in this species genome, playing a role in its trademark ability to selectively take up its own DNA. Here, we report high- ...[more]
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