Dataset Information

Methylomic Aging as a Window onto the Influence of Lifestyle: Tobacco and Alcohol Use Alter the Rate of Biological Aging.

ABSTRACT: OBJECTIVES:To examine the effect of the relationship between alcohol and cigarette consumption on biological aging using deoxyribonucleic acid methylation-based indices. DESIGN:Hierarchical linear regression modeling followed by fitting of higher-order effects. SETTING:Longitudinal studies of aging and the effect of psychosocial stress. PARTICIPANTS:Participants in two ethnically informative cohorts (n = 656 white, n = 180 black). MEASUREMENTS:Deviation of biological age from chronological age as a result of smoking and alcohol consumption. RESULTS:Greater cigarette consumption was associated with accelerated biological aging, with strong effects evident at even low levels of exposure. In contrast, alcohol consumption was associated with a mixed effect on biological aging and pronounced nonlinear effects. At low and heavy levels of alcohol consumption, there was accelerated biological aging, whereas at intermediate levels of consumption there was a relative decelerating effect. The decelerating effects of alcohol were particularly notable at loci for which methylation increased with age. CONCLUSION:These data support prior epidemiological studies indicating that moderate alcohol use is associated with healthy aging, but we urge caution in interpreting these results. Conversely, smoking has strong negative effects at all levels of consumption. These results also support the use of methylomic indices as a tool for assessing the impact of lifestyle on aging.

SUBMITTER: Beach SR

PROVIDER: S-EPMC4906951 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Methylomic Aging as a Window onto the Influence of Lifestyle: Tobacco and Alcohol Use Alter the Rate of Biological Aging.

Beach Steven R H SR Dogan Meeshanthini V MV Lei Man-Kit MK Cutrona Carolyn E CE Gerrard Meg M Gibbons Frederick X FX Simons Ronald L RL Brody Gene H GH Philibert Robert A RA

Journal of the American Geriatrics Society 20151114 12

<h4>Objectives</h4>To examine the effect of the relationship between alcohol and cigarette consumption on biological aging using deoxyribonucleic acid methylation-based indices.<h4>Design</h4>Hierarchical linear regression modeling followed by fitting of higher-order effects.<h4>Setting</h4>Longitudinal studies of aging and the effect of psychosocial stress.<h4>Participants</h4>Participants in two ethnically informative cohorts (n = 656 white, n = 180 black).<h4>Measurements</h4>Deviation of bio ...[more]

PMID: 26566992

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Project description:Individual hobbies and interests, the ways of spending leisure time develop personal resources influencing health and wellbeing. The literature analysis helped selecting thirteen personal resources that also affect the rate of aging: sports, order, creativity, intellect, handwork, kindness, Humor, spirituality, risk, nature, achievements, optimism, communication. In 1632 people, (840 women and 792 men) personal resources were assessed using a questionnaire developed in-house. Biological age was determined by health indicators. The personal typology was determined by testing functional asymmetry, physique, interaction style, emotionality, profession, marital status, gender, age, and place of residence. The data were processed by correlation and cluster analysis and methods of automatic artificial neural networks (ANN). Personal resources were used as input continuous variables. Personality types were used as input categorical variables. The index of relative biological aging (RBA) was applied as an output continuous variable. We also calculated the correlation between the RBA index and the applied personal resources in different types of personalities. For most female types including investigative occupations, psychomotor emotionality, living in urban areas, asthenic physique, negative correlations were found between most personal resources and the aging index. In men, resources that slow down aging are found only for certain types: enterprising and conventional professions, ambidexter and left-handed, intellectual emotionality, athletic physique. In conclusion, with the help of the trained ANN, we selected personal resources that slow down aging. For women of all types, there are common resources reducing RBA index including nature, intellect, and achievements. For men, ANN was unable to find common resources that slow down aging. However, with an individual selection of resources, a trained neural network gives a favorable forecast of the ability to slow down the biological aging of a particular man by changing his hobbies and interests and ways of spending free time.

Dataset Information

Methylomic Aging as a Window onto the Influence of Lifestyle: Tobacco and Alcohol Use Alter the Rate of Biological Aging.

Publications

Methylomic Aging as a Window onto the Influence of Lifestyle: Tobacco and Alcohol Use Alter the Rate of Biological Aging.

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