Ontology highlight
ABSTRACT:
SUBMITTER: Postula M
PROVIDER: S-EPMC4906979 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Postula Marek M Janicki Piotr Kazimierz PK Rosiak Marek M Eyileten Ceren C Zaremba Małgorzata M Kaplon-Cieslicka Agnieszka A Sugino Shigekazu S Kosior Dariusz Artur DA Opolski Grzegorz G Filipiak Krzysztof Jerzy KJ Mirowska-Guzel Dagmara D
Experimental and therapeutic medicine 20160511 1
The aim of the present study was to investigate a possible association between the accumulation of rare coding variants in the genes for arachidonate 5-lipoxygenase (<i>ALOX5</i>) and ALOX5-activating protein (<i>ALOX5AP</i>), and corresponding production of leukotrienes (LTs) in patients with type 2 diabetes mellitus (T2DM) receiving acetylsalicylic therapy. Twenty exons and corresponding introns of the selected genes were resequenced in 303 DNA samples from patients with T2DM using pooled poly ...[more]