Ontology highlight
ABSTRACT:
SUBMITTER: Guo ST
PROVIDER: S-EPMC4908438 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Guo S T ST Chi M N MN Yang R H RH Guo X Y XY Zan L K LK Wang C Y CY Xi Y F YF Jin L L Croft A A Tseng H-Y HY Yan X G XG Farrelly M M Wang F H FH Lai F F Wang J F JF Li Y P YP Ackland S S Scott R R Agoulnik I U IU Hondermarck H H Thorne R F RF Liu T T Zhang X D XD Jiang C C CC
Oncogene 20150928 23
Inositol polyphosphate 4-phosphatase type II (INPP4B) negatively regulates phosphatidylinositol 3-kinase signaling and is a tumor suppressor in some types of cancers. However, we have found that it is frequently upregulated in human colon cancer cells. Here we show that silencing of INPP4B blocks activation of Akt and serum- and glucocorticoid-regulated kinase 3 (SGK3), inhibits colon cancer cell proliferation and retards colon cancer xenograft growth. Conversely, overexpression of INPP4B increa ...[more]