Ontology highlight
ABSTRACT:
SUBMITTER: Lee KN
PROVIDER: S-EPMC4909548 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Organic & biomolecular chemistry 20160601 24
The one-pot two-step intramolecular aryl and heteroaryl C-H trifluoromethoxylation recently reported by our group has provided a general, scalable, and operationally simple approach to access a wide range of unprecedented and valuable OCF3-containing building blocks. Herein we describe our investigations to elucidate its reaction mechanism. Experimental data indicate that the O-trifluoromethylation of N-(hetero)aryl-N-hydroxylamine derivatives is a radical process, whereas the OCF3-migration ste ...[more]