Ontology highlight
ABSTRACT:
SUBMITTER: Ser Z
PROVIDER: S-EPMC4909568 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Ser Zheng Z Gao Xia X Johnson Christelle C Mehrmohamadi Mahya M Liu Xiaojing X Li Siqi S Locasale Jason W JW
Cell reports 20160602 11
Antimetabolites that affect nucleotide metabolism are frontline chemotherapy agents in several cancers and often successfully target one carbon metabolism. However, the precise mechanisms and resulting determinants of their therapeutic value are unknown. We show that 5-fluorouracil (5-FU), a commonly used antimetabolite therapeutic with varying efficacy, induces specific alterations to nucleotide metabolism by disrupting pyrimidine homeostasis. An integrative metabolomics analysis of the cellula ...[more]