Ontology highlight
ABSTRACT:
SUBMITTER: Yadav SP
PROVIDER: S-EPMC4909859 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Yadav Sharda Prasad SP Sharma Neel Kamal NK Liu Chunqiao C Dong Lijin L Li Tiansen T Swaroop Anand A
Development (Cambridge, England) 20160310 9
Defects in cilia centrosomal genes cause pleiotropic clinical phenotypes, collectively called ciliopathies. Cilia biogenesis is initiated by the interaction of positive and negative regulators. Centriolar coiled coil protein 110 (CP110) caps the distal end of the mother centriole and is known to act as a suppressor to control the timing of ciliogenesis. Here, we demonstrate that CP110 promotes cilia formation in vivo, in contrast to findings in cultured cells. Cp110(-/-) mice die shortly after b ...[more]