Dataset Information

Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPK? Signalling Pathway.

ABSTRACT:

Background

AMPactivated protein kinase ? (AMPK?) is closely involved in the process of cardiac hypertrophy. Asiatic acid (AA), a pentacyclic triterpene, was found to activate AMPK? in our preliminary experiment. However, its effects on the development of cardiac hypertrophy remain unclear. The present study was to determine whether AA could protect against cardiac hypertrophy.

Methods

Mice subjected to aortic banding were orally given AA (10 or 30mg/kg) for 7 weeks. In the inhibitory experiment, Compound C was intraperitoneally injected for 3 weeks after surgery.

Results

Our results showed that AA markedly inhibited hypertrophic responses induced by pressure overload or angiotensin II. AA also suppressed cardiac fibrosis in vivo and accumulation of collagen in vitro. The protective effects of AA were mediated by activation of AMPK? and inhibition of the mammalian target of rapamycin (mTOR) pathway and extracellular signal-regulated kinase (ERK) in vivo and in vitro. However, AA lost the protective effects after AMPK? inhibition or gene deficiency.

Conclusions

AA protects against cardiac hypertrophy by activating AMPK?, and has the potential to be used for the treatment of heart failure.

SUBMITTER: Ma ZG

PROVIDER: S-EPMC4910604 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKα Signalling Pathway.

Ma Zhen-Guo ZG Dai Jia J Wei Wen-Ying WY Zhang Wen-Bin WB Xu Si-Chi SC Liao Hai-Han HH Yang Zheng Z Tang Qi-Zhu QZ

International journal of biological sciences 20160525 7

<h4>Background</h4>AMPactivated protein kinase α (AMPKα) is closely involved in the process of cardiac hypertrophy. Asiatic acid (AA), a pentacyclic triterpene, was found to activate AMPKα in our preliminary experiment. However, its effects on the development of cardiac hypertrophy remain unclear. The present study was to determine whether AA could protect against cardiac hypertrophy.<h4>Methods</h4>Mice subjected to aortic banding were orally given AA (10 or 30mg/kg) for 7 weeks. In the inhibit ...[more]

PMID: 27313499

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