Ontology highlight
ABSTRACT:
SUBMITTER: Tsai AK
PROVIDER: S-EPMC4910704 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Tsai Alexander K AK Davila Eduardo E
Oncoimmunology 20160115 5
Adoptive cell transfer (ACT) is an emerging anticancer therapy that has shown promise in various malignancies. Redirecting antigen specificity by genetically engineering T cells to stably express receptors has become an effective variant of ACT. A novel extension of this approach is to utilize engineered T cells to produce and deliver anticancer therapeutics that enhance cytotoxic T cell function and simultaneously inhibit immunosuppressive processes. Here, we review the potential of using T cel ...[more]