Unknown

Dataset Information

0

Producer T cells: Using genetically engineered T cells as vehicles to generate and deliver therapeutics to tumors.


ABSTRACT: Adoptive cell transfer (ACT) is an emerging anticancer therapy that has shown promise in various malignancies. Redirecting antigen specificity by genetically engineering T cells to stably express receptors has become an effective variant of ACT. A novel extension of this approach is to utilize engineered T cells to produce and deliver anticancer therapeutics that enhance cytotoxic T cell function and simultaneously inhibit immunosuppressive processes. Here, we review the potential of using T cells as therapeutic-secreting vehicles for immunotherapies and present theoretical and established arguments in support of further development of this unique cell-based immunotherapy.

SUBMITTER: Tsai AK 

PROVIDER: S-EPMC4910704 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Producer T cells: Using genetically engineered T cells as vehicles to generate and deliver therapeutics to tumors.

Tsai Alexander K AK   Davila Eduardo E  

Oncoimmunology 20160115 5


Adoptive cell transfer (ACT) is an emerging anticancer therapy that has shown promise in various malignancies. Redirecting antigen specificity by genetically engineering T cells to stably express receptors has become an effective variant of ACT. A novel extension of this approach is to utilize engineered T cells to produce and deliver anticancer therapeutics that enhance cytotoxic T cell function and simultaneously inhibit immunosuppressive processes. Here, we review the potential of using T cel  ...[more]

Similar Datasets

| S-EPMC6195910 | biostudies-literature
| S-EPMC5514691 | biostudies-other
| S-EPMC2701484 | biostudies-literature
| S-EPMC5612825 | biostudies-literature
| S-EPMC3218656 | biostudies-literature
| S-EPMC6787137 | biostudies-literature
| S-EPMC2745508 | biostudies-literature
2018-06-17 | GSE94927 | GEO
| S-EPMC6909218 | biostudies-literature
| S-EPMC8050327 | biostudies-literature