Ontology highlight
ABSTRACT:
SUBMITTER: Astudillo L
PROVIDER: S-EPMC4911243 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Astudillo Luisana L Da Silva Thiago G TG Wang Zhiqiang Z Han Xiaoqing X Jin Ke K VanWye Jeffrey J Zhu Xiaoxia X Weaver Kelly K Oashi Taiji T Lopes Pedro E M PE Orton Darren D Neitzel Leif R LR Lee Ethan E Landgraf Ralf R Robbins David J DJ MacKerell Alexander D AD Capobianco Anthony J AJ
Cancer research 20160413 12
In many cancers, aberrant Notch activity has been demonstrated to play a role in the initiation and maintenance of the neoplastic phenotype and in cancer stem cells, which may allude to its additional involvement in metastasis and resistance to therapy. Therefore, Notch is an exceedingly attractive therapeutic target in cancer, but the full range of potential targets within the pathway has been underexplored. To date, there are no small-molecule inhibitors that directly target the intracellular ...[more]