Ontology highlight
ABSTRACT:
SUBMITTER: Djeghloul D
PROVIDER: S-EPMC4911502 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Djeghloul Dounia D Kuranda Klaudia K Kuzniak Isabelle I Barbieri Daniela D Naguibneva Irina I Choisy Caroline C Bories Jean-Christophe JC Dosquet Christine C Pla Marika M Vanneaux Valérie V Socié Gérard G Porteu Françoise F Garrick David D Goodhardt Michele M
Stem cell reports 20160601 6
The capacity of hematopoietic stem cells (HSC) to generate B lymphocytes declines with age, contributing to impaired immune function in the elderly. Here we show that the histone methyltransferase SUV39H1 plays an important role in human B lymphoid differentiation and that expression of SUV39H1 decreases with age in both human and mouse HSC, leading to a global reduction in H3K9 trimethylation and perturbed heterochromatin function. Further, we demonstrate that SUV39H1 is a target of microRNA mi ...[more]