Ontology highlight
ABSTRACT:
SUBMITTER: Bott LC
PROVIDER: S-EPMC4911547 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Bott Laura C LC Salomons Florian A FA Maric Dragan D Liu Yuhong Y Merry Diane D Fischbeck Kenneth H KH Dantuma Nico P NP
Scientific reports 20160617
Polyglutamine expansion in the androgen receptor (AR) causes spinal and bulbar muscular atrophy (SBMA), an X-linked neuromuscular disease that is fully manifest only in males. It has been suggested that proteins with expanded polyglutamine tracts impair ubiquitin-dependent proteolysis due to their propensity to aggregate, but recent studies indicate that the overall activity of the ubiquitin-proteasome system is preserved in SBMA models. Here we report that AR selectively interferes with the fun ...[more]