Ontology highlight
ABSTRACT:
SUBMITTER: Agger K
PROVIDER: S-EPMC4911927 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Agger Karl K Miyagi Satoru S Pedersen Marianne Terndrup MT Kooistra Susanne M SM Johansen Jens Vilstrup JV Helin Kristian K
Genes & development 20160602 11
Acute myeloid leukemias (AMLs) with a rearrangement of the mixed-linage leukemia (MLL) gene are aggressive hematopoietic malignancies. Here, we explored the feasibility of using the H3K9- and H3K36-specific demethylases Jmjd2/Kdm4 as putative drug targets in MLL-AF9 translocated leukemia. Using Jmjd2a, Jmjd2b, and Jmjd2c conditional triple-knockout mice, we show that Jmjd2/Kdm4 activities are required for MLL-AF9 translocated AML in vivo and in vitro. We demonstrate that expression of the interl ...[more]