Soluble Serum ?Klotho Is a Potential Predictive Marker of Disease Progression in Clear Cell Renal Cell Carcinoma.

ABSTRACT: Renal cell carcinoma (RCC) accounts for approximately 3% of adult malignancies, and clear cell RCC (ccRCC), that has a high metastatic index and high relapse rate, is the most common histological subtype. The identification of new biomarkers in ccRCC is fundamental for stratifying patients into prognostic risk groups and to guide therapy. The renoprotective antiaging gene, ?Klotho, has recently been found to work as a tumor suppressor in different human cancers. Here, we evaluated ?Klotho expression in tissue and serum of ccRCC patients and correlated it with disease progression. Tissue ?Klotho expression was studied by quantitative RT-PCR and immunohistochemistry. In addition, soluble serum ?Klotho levels were preoperatively measured in 160 patients who underwent nephrectomy for RCC with ELISA. Estimates of cancer-specific (CSS) and progression-free survival (PFS) were calculated according to the Kaplan-Meier method. Multivariate analysis was performed to identify the most significant variables for predicting CSS and PFS. ?Klotho protein levels were significantly decreased in RCC tissues compared with normal tissues (P?

SUBMITTER: Gigante M 

PROVIDER: S-EPMC4912252 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature