Ontology highlight
ABSTRACT:
SUBMITTER: Dufies M
PROVIDER: S-EPMC5928901 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Dufies Maeva M Nollet Marie M Ambrosetti Damien D Traboulsi Wael W Viotti Julien J Borchiellini Delphine D Grépin Renaud R Parola Julien J Giuliano Sandy S Helley-Russick Dominique D Bensalah Karim K Ravaud Alain A Bernhard Jean-Christophe JC Schiappa Renaud R Bardin Nathalie N Dignat-George Françoise F Rioux-Leclercq Nathalie N Oudard Stephane S Négrier Sylvie S Ferrero Jean-Marc JM Chamorey Emmanuel E Blot-Chabaud Marcel M Pagès Gilles G
Theranostics 20180328 9
The objective of the study was to use CD146 mRNA to predict the evolution of patients with non-metastatic clear cell renal cell carcinoma (M0 ccRCC) towards metastatic disease, and to use soluble CD146 (sCD146) to anticipate relapses on reference treatments by sunitinib or bevacizumab in patients with metastatic ccRCC (M1). <b>Methods</b>: A retrospective cohort of M0 patients was used to determine the prognostic role of intra-tumor CD146 mRNA. Prospective multi-center trials were used to define ...[more]