Ontology highlight
ABSTRACT:
SUBMITTER: Kurt Yilmaz N
PROVIDER: S-EPMC4912444 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Kurt Yilmaz Nese N Swanstrom Ronald R Schiffer Celia A CA
Trends in microbiology 20160415 7
Drug resistance is a major problem in health care, undermining therapy outcomes and necessitating novel approaches to drug design. Extensive studies on resistance to viral protease inhibitors, particularly those of HIV-1 and hepatitis C virus (HCV) protease, revealed a plethora of information on the structural and molecular mechanisms underlying resistance. These insights led to several strategies to improve viral protease inhibitors to counter resistance, such as exploiting the essential biolog ...[more]