Ontology highlight
ABSTRACT:
SUBMITTER: Abarrategi A
PROVIDER: S-EPMC4913005 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Abarrategi Ander A Tornin Juan J Martinez-Cruzado Lucia L Hamilton Ashley A Martinez-Campos Enrique E Rodrigo Juan P JP González M Victoria MV Baldini Nicola N Garcia-Castro Javier J Rodriguez Rene R
Stem cells international 20160605
Osteosarcoma (OS) is the most common type of primary solid tumor that develops in bone. Although standard chemotherapy has significantly improved long-term survival over the past few decades, the outcome for those patients with metastatic or recurrent OS remains dismally poor and, therefore, novel agents and treatment regimens are urgently required. A hypothesis to explain the resistance of OS to chemotherapy is the existence of drug resistant CSCs with progenitor properties that are responsible ...[more]