Versatile Structures of ?-Synuclein.
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ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC4913103 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Versatile Structures of α-Synuclein.
Wang Chuchu C Zhao Chunyu C Li Dan D Tian Zhiqi Z Lai Ying Y Diao Jiajie J Liu Cong C
Frontiers in molecular neuroscience 20160620
α-Synuclein (α-syn) is an intrinsically disordered protein abundantly distributed in presynaptic terminals. Aggregation of α-syn into Lewy bodies (LB) is a molecular hallmark of Parkinson's disease (PD). α-Syn features an extreme conformational diversity, which adapts to different conditions and fulfills versatile functions. However, the molecular mechanism of α-syn transformation and the relation between different structural species and their functional and pathogenic roles in neuronal activiti ...[more]
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