Ontology highlight
ABSTRACT:
SUBMITTER: Schweighauser M
PROVIDER: S-EPMC7116528 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Schweighauser Manuel M Shi Yang Y Tarutani Airi A Kametani Fuyuki F Murzin Alexey G AG Ghetti Bernardino B Matsubara Tomoyasu T Tomita Taisuke T Ando Takashi T Hasegawa Kazuko K Murayama Shigeo S Yoshida Mari M Hasegawa Masato M Scheres Sjors H W SHW Goedert Michel M
Nature 20200527 7825
Synucleinopathies, which include multiple system atrophy (MSA), Parkinson's disease, Parkinson's disease with dementia and dementia with Lewy bodies (DLB), are human neurodegenerative diseases<sup>1</sup>. Existing treatments are at best symptomatic. These diseases are characterized by the presence of, and believed to be caused by the formation of, filamentous inclusions of α-synuclein in brain cells<sup>2,3</sup>. However, the structures of α-synuclein filaments from the human brain are unknown ...[more]