Ontology highlight
ABSTRACT:
SUBMITTER: Jukes JP
PROVIDER: S-EPMC4913735 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Jukes John-Paul JP Gileadi Uzi U Ghadbane Hemza H Yu Ting-Fong TF Shepherd Dawn D Cox Liam R LR Besra Gurdyal S GS Cerundolo Vincenzo V
European journal of immunology 20160301 5
Invariant natural killer T (iNKT) cells recognize CD1d/glycolipid complexes and upon activation with synthetic agonists display immunostimulatory properties. We have previously described that the non-glycosidic CD1d-binding lipid, threitolceramide (ThrCer) activates murine and human iNKT cells. Here, we show that incorporating the headgroup of ThrCer into a conformationally more restricted 6- or 7-membered ring results in significantly more potent non-glycosidic analogs. In particular, ThrCer 6 ...[more]