Ontology highlight
ABSTRACT:
SUBMITTER: Saiz-Ladera C
PROVIDER: S-EPMC4913869 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Saiz-Ladera Cristina C Lara María Fernanda MF Garín Marina M Ruiz Sergio S Santos Mirentxu M Lorz Corina C García-Escudero Ramón R Martínez-Fernández Mónica M Bravo Ana A Fernández-Capetillo Oscar O Segrelles Carmen C Paramio Jesús M JM
Oncogene 20131014 37
The retinoblastoma gene product (pRb) controls proliferation and differentiation processes in stratified epithelia. Importantly, and in contrast to other tissues, Rb deficiency does not lead to spontaneous skin tumor formation. As the cyclin-dependent kinase inhibitor p21 regulates proliferation and differentiation in the absence of pRb, we analyzed the consequences of deleting p21 in pRb-ablated stratified epithelia (hereafter pRb(ΔEpi);p21-/-). These mice display an enhancement of the phenotyp ...[more]