Ontology highlight
ABSTRACT:
SUBMITTER: Lough KJ
PROVIDER: S-EPMC6959978 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Lough Kendall J KJ Byrd Kevin M KM Descovich Carlos P CP Spitzer Danielle C DC Bergman Abby J AJ Beaudoin Gerard Mj GM Reichardt Louis F LF Williams Scott E SE
eLife 20191213
During organogenesis, precise control of spindle orientation balances proliferation and differentiation. In the developing murine epidermis, planar and perpendicular divisions yield symmetric and asymmetric fate outcomes, respectively. Classically, division axis specification involves centrosome migration and spindle rotation, events occurring early in mitosis. Here, we identify a novel orientation mechanism which corrects erroneous anaphase orientations during telophase. The directionality of r ...[more]