Ontology highlight
ABSTRACT:
SUBMITTER: Anand T
PROVIDER: S-EPMC4913943 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Anand Taruna T Talluri Thirumala R TR Kumar Dharmendra D Garrels Wiebke W Mukherjee Ayan A Debowski Katharina K Behr Rüdiger R Kues Wilfried A WA
PloS one 20160620 6
Curative approaches for eye cataracts and other eye abnormalities, such as myopia and hyperopia currently suffer from a lack of appropriate models. Here, we present a new approach for in vitro growth of lentoid bodies from induced pluripotent stem (iPS) cells as a tool for ophthalmological research. We generated a transgenic mouse line with lens-specific expression of a fluorescent reporter driven by the alphaA crystallin promoter. Fetal fibroblasts were isolated from transgenic fetuses, reprogr ...[more]