New paradigm to assess brain cell morphology by diffusion-weighted MR spectroscopy in vivo.
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ABSTRACT:
SUBMITTER: Palombo M
PROVIDER: S-EPMC4914152 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
New paradigm to assess brain cell morphology by diffusion-weighted MR spectroscopy in vivo.
Palombo Marco M Ligneul Clémence C Najac Chloé C Le Douce Juliette J Flament Julien J Escartin Carole C Hantraye Philippe P Brouillet Emmanuel E Bonvento Gilles G Valette Julien J
Proceedings of the National Academy of Sciences of the United States of America 20160525 24
The brain is one of the most complex organs, and tools are lacking to assess its cellular morphology in vivo. Here we combine original diffusion-weighted magnetic resonance (MR) spectroscopy acquisition and novel modeling strategies to explore the possibility of quantifying brain cell morphology noninvasively. First, the diffusion of cell-specific metabolites is measured at ultra-long diffusion times in the rodent and primate brain in vivo to observe how cell long-range morphology constrains met ...[more]
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