Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC4914158 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Li Hui H Wang Shuyi S Kong Rui R Ding Wenge W Lee Fang-Hua FH Parker Zahra Z Kim Eunlim E Learn Gerald H GH Hahn Paul P Policicchio Ben B Brocca-Cofano Egidio E Deleage Claire C Hao Xingpei X Chuang Gwo-Yu GY Gorman Jason J Gardner Matthew M Lewis Mark G MG Hatziioannou Theodora T Santra Sampa S Apetrei Cristian C Pandrea Ivona I Alam S Munir SM Liao Hua-Xin HX Shen Xiaoying X Tomaras Georgia D GD Farzan Michael M Chertova Elena E Keele Brandon F BF Estes Jacob D JD Lifson Jeffrey D JD Doms Robert W RW Montefiori David C DC Haynes Barton F BF Sodroski Joseph G JG Kwong Peter D PD Hahn Beatrice H BH Shaw George M GM
Proceedings of the National Academy of Sciences of the United States of America 20160531 24
Most simian-human immunodeficiency viruses (SHIVs) bearing envelope (Env) glycoproteins from primary HIV-1 strains fail to infect rhesus macaques (RMs). We hypothesized that inefficient Env binding to rhesus CD4 (rhCD4) limits virus entry and replication and could be enhanced by substituting naturally occurring simian immunodeficiency virus Env residues at position 375, which resides at a critical location in the CD4-binding pocket and is under strong positive evolutionary pressure across the br ...[more]