Ontology highlight
ABSTRACT:
SUBMITTER: Lin X
PROVIDER: S-EPMC4914273 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Lin Xianfeng X Fang Xiangqian X Wang Qiang Q Hu Zhijun Z Chen Kai K Shan Zhi Z Chen Shuai S Wang Jiying J Mo Jian J Ma Jianjun J Xu Wenbing W Qin An A Fan Shunwu S
Oncotarget 20160301 11
Intervertebral disc degeneration is associated with back pain and disc herniation. This study established a modified protocol for intervertebral disc (IVD) decellularization and prepared its extracellular matrix (ECM). By culturing mesenchymal stem cells (MSCs)(3, 7, 14 and 21 days) and human degenerative IVD cells (7 days) in the ECM, implanting it subcutaneously in rabbit and injecting ECM microparticles into degenerative disc, the biological safety and efficacy of decellularized IVD was evalu ...[more]