Unknown

Dataset Information

0

Human naive regulatory T-cells feature high steady-state turnover and are maintained by IL-7.


ABSTRACT: Naïve FoxP3-expressing regulatory T-cells (Tregs) are essential to control immune responses via continuous replenishment of the activated-Treg pool with thymus-committed suppressor cells. The mechanisms underlying naïve-Treg maintenance throughout life in face of the age-associated thymic involution remain unclear. We found that in adults thymectomized early in infancy the naïve-Treg pool is remarkably well preserved, in contrast to conventional naïve CD4 T-cells. Naïve-Tregs featured high levels of cycling and pro-survival markers, even in healthy individuals, and contrasted with other circulating naïve/memory CD4 T-cell subsets in terms of their strong ?c-cytokine-dependent signaling, particularly in response to IL-7. Accordingly, ex-vivo stimulation of naïve-Tregs with IL-7 induced robust cytokine-dependent signaling, Bcl-2 expression, and phosphatidylinositol 3-kinase (PI3K)-dependent proliferation, whilst preserving naïve phenotype and suppressive capacity. Altogether, our data strongly implicate IL-7 in the thymus-independent long-term survival of functional naïve-Tregs, and highlight the potential of targeting the IL-7 pathway to modulate Tregs in different clinical settings.

SUBMITTER: Silva SL 

PROVIDER: S-EPMC4914276 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications


Naïve FoxP3-expressing regulatory T-cells (Tregs) are essential to control immune responses via continuous replenishment of the activated-Treg pool with thymus-committed suppressor cells. The mechanisms underlying naïve-Treg maintenance throughout life in face of the age-associated thymic involution remain unclear. We found that in adults thymectomized early in infancy the naïve-Treg pool is remarkably well preserved, in contrast to conventional naïve CD4 T-cells. Naïve-Tregs featured high level  ...[more]

Similar Datasets

| S-EPMC5742542 | biostudies-literature
| S-EPMC7670637 | biostudies-literature
| S-EPMC7988239 | biostudies-literature
| S-EPMC7595971 | biostudies-literature
| S-EPMC4273380 | biostudies-literature
| S-EPMC4397865 | biostudies-literature
| S-EPMC4108575 | biostudies-literature
| S-EPMC6985113 | biostudies-literature
| S-EPMC3923301 | biostudies-literature
| S-EPMC5207384 | biostudies-literature