Ontology highlight
ABSTRACT:
SUBMITTER: Silva SL
PROVIDER: S-EPMC4914276 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Silva Susana L SL Albuquerque Adriana S AS Serra-Caetano Ana A Foxall Russell B RB Pires Ana R AR Matoso Paula P Fernandes Susana M SM Ferreira João J Cheynier Rémi R Victorino Rui M M RM Caramalho Iris I Barata João T JT Sousa Ana E AE
Oncotarget 20160301 11
Naïve FoxP3-expressing regulatory T-cells (Tregs) are essential to control immune responses via continuous replenishment of the activated-Treg pool with thymus-committed suppressor cells. The mechanisms underlying naïve-Treg maintenance throughout life in face of the age-associated thymic involution remain unclear. We found that in adults thymectomized early in infancy the naïve-Treg pool is remarkably well preserved, in contrast to conventional naïve CD4 T-cells. Naïve-Tregs featured high level ...[more]