Autophagy: a decisive process for stemness.
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ABSTRACT:
SUBMITTER: Garcia-Prat L
PROVIDER: S-EPMC4914284 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Autophagy: a decisive process for stemness.
García-Prat Laura L Martínez-Vicente Marta M Muñoz-Cánoves Pura P
Oncotarget 20160301 11
Mature skeletal muscle is a stable tissue imposing low homeostatic demand on its stem cells, which remain in a quiescent state in their niche over time. We have shown that these long-lived resting stem cells attenuate proteotoxicity and avoid senescence through basal autophagy. This protective "clean-up" system is lost during aging, resulting in stem cell regenerative decline. Thus, autophagy is required for muscle stem cell homeostasis maintenance. ...[more]
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