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Mycophenolic Acid and Its Derivatives as Potential Chemotherapeutic Agents Targeting Inosine Monophosphate Dehydrogenase in Trypanosoma congolense.

ABSTRACT: This study aimed to evaluate the trypanocidal activity of mycophenolic acid (MPA) and its derivatives for Trypanosoma congolense The proliferation of T. congolense was completely inhibited by adding <1 ?M MPA and its derivatives. In addition, the IMP dehydrogenase in T. congolense was molecularly characterized as the target of these compounds. The results suggest that MPA and its derivatives have the potential to be new candidates as novel trypanocidal drugs.

SUBMITTER: Suganuma K

PROVIDER: S-EPMC4914658 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Mycophenolic Acid and Its Derivatives as Potential Chemotherapeutic Agents Targeting Inosine Monophosphate Dehydrogenase in Trypanosoma congolense.

Suganuma Keisuke K Sarwono Albertus Eka Yudistira AE Mitsuhashi Shinya S Jąkalski Marcin M Okada Tadashi T Nthatisi Molefe M Yamagishi Junya J Ubukata Makoto M Inoue Noboru N

Antimicrobial agents and chemotherapy 20160620 7

This study aimed to evaluate the trypanocidal activity of mycophenolic acid (MPA) and its derivatives for Trypanosoma congolense The proliferation of T. congolense was completely inhibited by adding <1 μM MPA and its derivatives. In addition, the IMP dehydrogenase in T. congolense was molecularly characterized as the target of these compounds. The results suggest that MPA and its derivatives have the potential to be new candidates as novel trypanocidal drugs. ...[more]

PMID: 27139487

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Correction to Repurposing Cryptosporidium Inosine 5′-Monophosphate Dehydrogenase Inhibitors as Potential Antibacterial Agents

Project description: Not available

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