Ontology highlight
ABSTRACT:
SUBMITTER: Yu R
PROVIDER: S-EPMC6467267 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Yu Runhan R Kim Youngchang Y Maltseva Natalia N Braunstein Philip P Joachimiak Andrzej A Hedstrom Lizbeth L
Chemical research in toxicology 20190225 3
Reactive nitrogen species (RNS) are produced during infection and inflammation, and the effects of these agents on proteins, DNA, and lipids are well recognized. In contrast, the effects of RNS damaged metabolites are less appreciated. 5-Amino-3-β-(d-ribofuranosyl)-3 H-imidazo-[4,5- d][1,3]oxazine-7-one (oxanosine) and its nucleotides are products of guanosine nitrosation. Here we demonstrate that oxanosine monophosphate (OxMP) is a potent reversible competitive inhibitor of IMPDH. The value of ...[more]