Ontology highlight
ABSTRACT:
SUBMITTER: Wagner E
PROVIDER: S-EPMC4915195 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Wagner Elizabeth E Glotzer Michael M
The Journal of cell biology 20160613 6
The GTPase RhoA promotes contractile ring assembly and furrow ingression during cytokinesis. Although many factors that regulate RhoA during cytokinesis have been characterized, the spatiotemporal regulatory logic remains undefined. We have developed an optogenetic probe to gain tight spatial and temporal control of RhoA activity in mammalian cells and demonstrate that cytokinetic furrowing is primarily regulated at the level of RhoA activation. Light-mediated recruitment of a RhoGEF domain to t ...[more]