Ontology highlight
ABSTRACT:
SUBMITTER: Caydasi AK
PROVIDER: S-EPMC3377990 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Caydasi Ayse Koca AK Lohel Maiko M Grünert Gerd G Dittrich Peter P Pereira Gislene G Ibrahim Bashar B
Molecular systems biology 20120508
The orientation of the mitotic spindle with respect to the polarity axis is crucial for the accuracy of asymmetric cell division. In budding yeast, a surveillance mechanism called the spindle position checkpoint (SPOC) prevents exit from mitosis when the mitotic spindle fails to align along the mother-to-daughter polarity axis. SPOC arrest relies upon inhibition of the GTPase Tem1 by the GTPase-activating protein (GAP) complex Bfa1-Bub2. Importantly, reactions signaling mitotic exit take place a ...[more]