Childhood trauma and neural responses to personalized stress, favorite-food and neutral-relaxing cues in adolescents.

ABSTRACT: Previous studies have found childhood trauma to be associated with functional and structural abnormalities in corticostriatal-limbic brain regions, which may explain the associations between trauma and negative mental and physical health outcomes. However, functional neuroimaging of maltreatment-related trauma has been limited by largely using generic and predominantly aversive stimuli. Personalized stress, favorite-food, and neutral/relaxing cues during functional magnetic resonance imaging were used to probe the neural correlates of emotional/motivational states in adolescents with varying exposure to maltreatment-related trauma. Sixty-four adolescents were stratified into high- or low-trauma-exposed groups. Cue-related measures of subjective anxiety and craving were collected. Relative

SUBMITTER: Elsey J 

PROVIDER: S-EPMC4915266 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature