Potent inhibition of norovirus by dipeptidyl ?-hydroxyphosphonate transition state mimics.
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ABSTRACT:
SUBMITTER: Mandadapu SR
PROVIDER: S-EPMC4916958 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics.
Mandadapu Sivakoteswara Rao SR Gunnam Mallikarjuna Reddy MR Galasiti Kankanamalage Anushka C AC Uy Roxanne Adeline Z RA Alliston Kevin R KR Lushington Gerald H GH Kim Yunjeong Y Chang Kyeong-Ok KO Groutas William C WC
Bioorganic & medicinal chemistry letters 20130822 21
The design, synthesis, and evaluation of a series of dipeptidyl α-hydroxyphosphonates is reported. The synthesized compounds displayed high anti-norovirus activity in a cell-based replicon system, as well as high enzyme selectivity. ...[more]
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