Ontology highlight
ABSTRACT:
SUBMITTER: Eggert E
PROVIDER: S-EPMC4917279 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20160503 10
Protein lysine methyltransferases have recently emerged as a new target class for the development of inhibitors that modulate gene transcription or signaling pathways. SET and MYND domain containing protein 2 (SMYD2) is a catalytic SET domain containing methyltransferase reported to monomethylate lysine residues on histone and nonhistone proteins. Although several studies have uncovered an important role of SMYD2 in promoting cancer by protein methylation, the biology of SMYD2 is far from being ...[more]