Ontology highlight
ABSTRACT:
SUBMITTER: Cunin P
PROVIDER: S-EPMC4917652 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Cunin P P Beauvillain C C Miot C C Augusto J-F JF Preisser L L Blanchard S S Pignon P P Scotet M M Garo E E Fremaux I I Chevailler A A Subra J-F JF Blanco P P Wilson M R MR Jeannin P P Delneste Y Y
Cell death & disease 20160505
Clusterin (Clu), an extracellular chaperone, exhibits characteristics of soluble innate immunity receptors, as assessed by its ability to bind some bacteria strains. In this study, we report that Clu also binds specifically to late apoptotic cells but not to live, early apoptotic, or necrotic cells. Histones, which accumulate on blebs during the apoptotic process, represent privileged Clu-binding motifs at the surface of late apoptotic cells. As a consequence, Clu potentiates, both in vitro and ...[more]