Ontology highlight
ABSTRACT:
SUBMITTER: Takeuchi R
PROVIDER: S-EPMC4918136 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Takeuchi Ryoko R Tada Mari M Shiga Atsushi A Toyoshima Yasuko Y Konno Takuya T Sato Tomoe T Nozaki Hiroaki H Kato Taisuke T Horie Masao M Shimizu Hiroshi H Takebayashi Hirohide H Onodera Osamu O Nishizawa Masatoyo M Kakita Akiyoshi A Takahashi Hitoshi H
Acta neuropathologica communications 20160623 1
Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are types of major TDP-43 (43-kDa TAR DNA-binding protein) proteinopathy. Cortical TDP-43 pathology has been analyzed in detail in cases of FTLD-TDP, but is still unclear in cases of ALS. We attempted to clarify the cortical and subcortical TDP-43 pathology in Japanese cases of sporadic ALS (n = 96) using an antibody specific to phosphorylated TDP-43 (pTDP-43). The cases were divided into two groups: those without p ...[more]