Unknown

Dataset Information

0

An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis.


ABSTRACT: The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essential for spindle assembly and chromosome segregation. Moreover, we identify KANSL3 as a microtubule minus-end-binding protein, revealing a new class of mitosis-specific microtubule minus-end regulators. By adopting distinct functions in interphase and mitosis, KANSL proteins provide a link to coordinate the tasks of faithful expression and inheritance of the genome during different phases of the cell cycle.

SUBMITTER: Meunier S 

PROVIDER: S-EPMC4918316 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

altmetric image

Publications

An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis.

Meunier Sylvain S   Shvedunova Maria M   Van Nguyen Nhuong N   Avila Leonor L   Vernos Isabelle I   Akhtar Asifa A  

Nature communications 20150805


The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essential for spindle assembly and chromosome segregation. Moreover, we identify KANSL3 as a microtubule minu  ...[more]

Similar Datasets

| S-EPMC3383595 | biostudies-literature
| S-EPMC7063570 | biostudies-literature
| S-EPMC9247359 | biostudies-literature
| S-EPMC5706958 | biostudies-literature
| S-EPMC7954811 | biostudies-literature
| S-EPMC3930908 | biostudies-literature
| S-EPMC3828766 | biostudies-literature
| S-EPMC2148210 | biostudies-literature
| S-EPMC6754230 | biostudies-literature
| S-EPMC4250830 | biostudies-literature