Ontology highlight
ABSTRACT:
SUBMITTER: Meunier S
PROVIDER: S-EPMC4918316 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Meunier Sylvain S Shvedunova Maria M Van Nguyen Nhuong N Avila Leonor L Vernos Isabelle I Akhtar Asifa A
Nature communications 20150805
The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essential for spindle assembly and chromosome segregation. Moreover, we identify KANSL3 as a microtubule minu ...[more]