Ontology highlight
ABSTRACT:
SUBMITTER: Andiappan AK
PROVIDER: S-EPMC4918343 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Andiappan Anand Kumar AK Melchiotti Rossella R Poh Tuang Yeow TY Nah Michelle M Puan Kia Joo KJ Vigano Elena E Haase Doreen D Yusof Nurhashikin N San Luis Boris B Lum Josephine J Kumar Dilip D Foo Shihui S Zhuang Li L Vasudev Anusha A Irwanto Astrid A Lee Bernett B Nardin Alessandra A Liu Hong H Zhang Furen F Connolly John J Liu Jianjun J Mortellaro Alessandra A Wang De Yun Y Poidinger Michael M Larbi Anis A Zolezzi Francesca F Rotzschke Olaf O
Nature communications 20150810
Neutrophils are an abundant immune cell type involved in both antimicrobial defence and autoimmunity. The regulation of their gene expression, however, is still largely unknown. Here we report an eQTL study on isolated neutrophils from 114 healthy individuals of Chinese ethnicity, identifying 21,210 eQTLs on 832 unique genes. Unsupervised clustering analysis of these eQTLs confirms their role in inflammatory responses and immunological diseases but also indicates strong involvement in dermatolog ...[more]