Combining HDAC inhibitors with oncolytic virotherapy for cancer therapy.
Ontology highlight
ABSTRACT:
SUBMITTER: Nakashima H
PROVIDER: S-EPMC4918398 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Combining HDAC inhibitors with oncolytic virotherapy for cancer therapy.
Nakashima Hiroshi H Nguyen Tran T Chiocca Ennio Antonio EA
Oncolytic virotherapy 20151120
Histone deacetylase (HDAC) enzymes play a critical role in the epigenetic regulation of cellular functions and signaling pathways in many cancers. HDAC inhibitors (HDACi) have been validated for single use or in combination with other drugs in oncologic therapeutics. An even more novel combination therapy with HDACi is to use them with an oncolytic virus. HDACi may lead to an amplification of tumor-specific lytic effects by facilitating increased cycles of viral replication, but there may also b ...[more]
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