Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC4428588 | biostudies-other | 2012 Aug
REPOSITORIES: biostudies-other
Li Shoudong S Tong Jessica J Rahman Masmudur M MM Shepherd Trevor G TG McFadden Grant G
Oncolytic virotherapy 20120801
In the past two decades, more than 20 viruses with selective tropism for tumor cells have been developed as oncolytic viruses (OVs) for treatments of a variety of malignancies. Of these viruses, eleven have been tested in human ovarian cancer models in preclinical studies. So far, nine phase I or II clinical trials have been conducted or initiated using four different types of OVs in patients with recurrent ovarian cancers. In this article, we summarize the different OVs that are being assessed ...[more]