Ontology highlight
ABSTRACT:
SUBMITTER: van der Linden WA
PROVIDER: S-EPMC4918641 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
van der Linden Wouter A WA Schulze Christopher J CJ Herbert Andrew S AS Krause Tyler B TB Wirchnianski Ariel A AA Dye John M JM Chandran Kartik K Bogyo Matthew M
ACS infectious diseases 20160120 3
The recent Ebola virus outbreak in western Africa highlights the need for novel therapeutics that target Ebola virus and other filoviruses. Filoviruses require processing by host cell-derived cysteine cathepsins for productive infection. Here we report the generation of a focused library of cysteine cathepsin inhibitors and subsequent screening to identify compounds with potent activity against viral entry and replication. Our top compounds show highly potent and broad-spectrum activity against ...[more]