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Cysteine Cathepsin Inhibitors as Anti-Ebola Agents.

ABSTRACT: The recent Ebola virus outbreak in western Africa highlights the need for novel therapeutics that target Ebola virus and other filoviruses. Filoviruses require processing by host cell-derived cysteine cathepsins for productive infection. Here we report the generation of a focused library of cysteine cathepsin inhibitors and subsequent screening to identify compounds with potent activity against viral entry and replication. Our top compounds show highly potent and broad-spectrum activity against cysteine cathepsins and were able to effectively block entry of Ebola and Marburg viruses. These agents are promising leads for development as antifilovirus therapeutics.

SUBMITTER: van der Linden WA

PROVIDER: S-EPMC4918641 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Cysteine Cathepsin Inhibitors as Anti-Ebola Agents.

van der Linden Wouter A WA Schulze Christopher J CJ Herbert Andrew S AS Krause Tyler B TB Wirchnianski Ariel A AA Dye John M JM Chandran Kartik K Bogyo Matthew M

ACS infectious diseases 20160120 3

The recent Ebola virus outbreak in western Africa highlights the need for novel therapeutics that target Ebola virus and other filoviruses. Filoviruses require processing by host cell-derived cysteine cathepsins for productive infection. Here we report the generation of a focused library of cysteine cathepsin inhibitors and subsequent screening to identify compounds with potent activity against viral entry and replication. Our top compounds show highly potent and broad-spectrum activity against ...[more]

PMID: 27347558

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