A mutational signature in gastric cancer suggests therapeutic strategies.
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ABSTRACT:
SUBMITTER: Alexandrov LB
PROVIDER: S-EPMC4918743 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
A mutational signature in gastric cancer suggests therapeutic strategies.
Alexandrov Ludmil B LB Nik-Zainal Serena S Siu Hoi Cheong HC Leung Suet Yi SY Stratton Michael R MR
Nature communications 20151029
Targeting defects in the DNA repair machinery of neoplastic cells, for example, those due to inactivating BRCA1 and/or BRCA2 mutations, has been used for developing new therapies in certain types of breast, ovarian and pancreatic cancers. Recently, a mutational signature was associated with failure of double-strand DNA break repair by homologous recombination based on its high mutational burden in samples harbouring BRCA1 or BRCA2 mutations. In pancreatic cancer, all responders to platinum thera ...[more]
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