Ontology highlight
ABSTRACT:
SUBMITTER: Som A
PROVIDER: S-EPMC4919221 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Som Avik A Raliya Ramesh R Tian Limei L Akers Walter W Ippolito Joseph E JE Singamaneni Srikanth S Biswas Pratim P Achilefu Samuel S
Nanoscale 20160108 25
The acidic extracellular environment of tumors potentiates their aggressiveness and metastasis, but few methods exist to selectively modulate the extracellular pH (pHe) environment of tumors. Transient flushing of biological systems with alkaline fluids or proton pump inhibitors is impractical and nonselective. Here we report a nanoparticles-based strategy to intentionally modulate the pHe in tumors. Biochemical simulations indicate that the dissolution of calcium carbonate nanoparticles (nano-C ...[more]