Uncovering the Role of Bicarbonate in Calcium Carbonate Formation at Near-Neutral pH.

ABSTRACT: Mechanistic pathways relevant to mineralization are not well-understood fundamentally, let alone in the context of their biological and geological environments. Through quantitative analysis of ion association at near-neutral pH, we identify the involvement of HCO₃ ^- ions in CaCO₃ nucleation. Incorporation of HCO₃ ^- ions into the structure of amorphous intermediates is corroborated by solid-state nuclear magnetic resonance spectroscopy, complemented by quantum mechanical calculations and molecular dynamics simulations. We identify the roles of HCO₃ ^- ions as being through (i) competition for ion association during the formation of ion pairs and ion clusters prior to nucleation and (ii) incorporation as a significant structural component of amorphous mineral particles. The roles of HCO₃ ^- ions as active soluble species and structural constituents in CaCO₃ formation are of fundamental importance and provide a basis for a better understanding of physiological and geological mineralization.

SUBMITTER: Huang YC 

PROVIDER: S-EPMC8362096 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature