Ontology highlight
ABSTRACT:
SUBMITTER: Cao S
PROVIDER: S-EPMC4919655 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Cao Song S Wendl Michael C MC Wyczalkowski Matthew A MA Wylie Kristine K Ye Kai K Jayasinghe Reyka R Xie Mingchao M Wu Song S Niu Beifang B Grubb Robert R Johnson Kimberly J KJ Gay Hiram H Chen Ken K Rader Janet S JS Dipersio John F JF Chen Feng F Ding Li L
Scientific reports 20160624
We applied a newly developed bioinformatics system called VirusScan to investigate the viral basis of 6,813 human tumors and 559 adjacent normal samples across 23 cancer types and identified 505 virus positive samples with distinctive, organ system- and cancer type-specific distributions. We found that herpes viruses (e.g., subtypes HHV4, HHV5, and HHV6) that are highly prevalent across cancers of the digestive tract showed significantly higher abundances in tumor versus adjacent normal samples, ...[more]