Ontology highlight
ABSTRACT:
SUBMITTER: Lee HJ
PROVIDER: S-EPMC4920341 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Lee Hui-Jie HJ Kishino Hirohisa H Rodrigue Nicolas N Thorne Jeffrey L JL
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20160701 1699
Different types of nucleotide substitutions experience different patterns of rate change over time. We propose clustering context-dependent (or context-independent) nucleotide substitution types according to how their rates change and then using the grouping for divergence time estimation. With our models, relative rates among types that are in the same group are fixed, whereas absolute rates of the types within a group change over time according to a shared relaxed molecular clock. We illustrat ...[more]