Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms.
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ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC4921241 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
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Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms.
Wang Qi Q Yu Wan-Ni WN Chen Xinyu X Peng Xiao-Ding XD Jeon Sang-Min SM Birnbaum Morris J MJ Guzman Grace G Hay Nissim N
Cancer cell 20160317 4
Akt is frequently hyperactivated in human cancers and is targeted for cancer therapy. However, the physiological consequences of systemic Akt isoform inhibition were not fully explored. We showed that while combined Akt1 and Akt3 deletion in adult mice is tolerated, combined Akt1 and Akt2 deletion induced rapid mortality. Akt2(-/-) mice survived hepatic Akt1 deletion but all developed spontaneous hepatocellular carcinoma (HCC), which is associated with FoxO-dependent liver injury and inflammatio ...[more]
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